Abstract:
Diabetes is a complex metabolic disorder affecting the glucose status of the human body. Chronic hyperglycaemia related to diabetes is associated with end organ failure. The aim of this study to estimate the effect of Lepidium sativum(garden cress) and Glycyrrhiza glabra (Licorice )on bodyweight, feed intake, lipid profiles, renal, hepatic function markersand the glucose levels in diabetic rats. Forty two (42) adult male albino rats (Sparague Dawley Strain), weighing 150 ± 5 g, were used. Rats of diabetic group were equally divided into 6 subgroups each one include 6 rats. The first group received basal diet as negative control group for 28days.Body weight, lipid profile & renal function (urea, uric acid creatinine) ALT & AST activities in addition to glucose and histological structure of liver and pancrease were estimated .Data showed that diabetic rats without treatments significantly increased liver enzymes and lipid profile concentration compared with negative control, while significantly decreasing final body weight and HDL; meanwhile treatment with Lepidium sativum(garden cress) , Glycyrrhiza glabra (Licorice ) and their mixture significantly decreased the lipid profile , liver enzymes whereas administration of herbal powder and its mixture significantly ameliorated these hepatic and pancreatic structures.So, Treatment with Glycyrrhiza glabra (Licorice ) followed by herbal mixture and Lepidium sativum(garden cress) improved diabetes and its associated metabolic problems in different degrees. Also they might be a safe combination on the organs whose functions were examined, as a way to surmount the diabetes state; and it has a distinct anti-diabetes effect.