“Early Sweet" grapevine is one of the most popular and delicious grape varieties in Egypt. However, it is known for its low yield, which may be attributed to the adverse effects of unfavorable environmental conditions. Micronutrients, like iron, zinc, manganese, molybdenum, and amino acids, have been shown to mitigate the negative effects of unfavorable environmental conditions. A study was conducted in the 2021 and 2022 seasons to assess the impact of applying single and combined treatments of molybdenum (Mo) at 30 ppm, mixed micronutrients (MM) at 150 ppm, and amino acids (AA) at 500 ppm on the growth, yield, and quality of “Early Sweet" grapevines. The results revealed that both individual and combined applications of Mo, MM, and AA significantly enhanced leaf area, increased the concentrations of total chlorophylls, total carotenoids, N, P, K, Mg, Fe Zn, and Mn in the leaves, and improved both yield and grape quality compared to untreated vines. Among the treatments, amino acids (AA) showed the most pronounced effect. The combination of Mo, MM, and AA was more effective compared to applying each component individually. Three sprays of a combination including molybdenum at 30 ppm, mixed micronutrients (Fe, Zn, and Mn) at 150 ppm, and amino acids at 500 ppm were significantly boosted in enhancing the quantitative and qualitative yield of “Early Sweet" grapevines.