A field study was conducted at Shandaweel Agricultural Research Station, Sohag, Egypt in 2020 and 2021 to evaluate the effects of irrigation interval (10, 15 and 20 day) and some weed managements on soybean yield and associated weeds. The results revealed that all measured soybean traits and associated weeds were significantly affected by irrigation interval and weeding treatments as well as their interactions.  Irrigation at 15-day interval produced the highest values of soybean yield and its attributes; seed protein and oil contents. Also, it gave a satisfy result in reducing the weeds biomass. Hand hoeing twice followed by pendimethalin pre + one hoeing at 30 days after sowing (DAS) were the best treatments in controlling weeds and improving soybean yield, its components and seed quality.  The highest seed yield of 2.04 t fedan^-1 (fed^-1) (average of the two seasons), with best quality of soybean (cv. Giza 111) could be achieved from the combined treatment of 15-day interval with hand hoeing twice or with pendimethalin (pre) + one hoeing at 30 DAS.  This conclusion could be recommended for soybean production in similar agro-ecosystems.