The present study was conducted during three successive 
seasons 2020, 2021, and 2022 on thirty-six uniform 6-year-old
Flame seedless grapevines, in a Private vineyard in Gohaina 
region, Sohag, Egypt. This study examined how grapevines 
respond physiologically, in terms of growth, yield, and quality, to 
Hydrogen Cyanamide and seaweed extract (Amphora 
coffeaeformis) as dormancy breaking, as well as Chlorella 
vulgaris, Nano fertilizers (nano Fe+ Zn), and conventional 
fertilizers (EDTA Fe + Zn) applied three times at on the same 
vines at fruit set, berry size 6:8 mm and at veraison stage as 
single or combined.The highest value of growth and yield 
parameters and chemical characteristics were recorded to 
combined application of (Hydrogen Cyanamide) dormix 5% 1st
week of Jan.× Chlorella vulgaris at 1ml/l and (nano Fe + Zn)1ppm
(as an average of the three studied seasons) aspects than using 
each material alone. It is concluded that the foliar combined 
application Hydrogen Cyanamide 5% 1st week of Jan. once 
and Chlorella vulgaris at 1ml/l and (nano Fe + Zn) 1ppm applied 
three times on the same vines at fruit set, berry size 6:8 mm and 
at veraison stage led to clear enhancements in the majority of the 
tested vegetative and fruiting parameters of Flame seedless 
grapevines.