A pot experiment was conducted in sandy soil to assess the effect of Nano Nitrogen loaded on modified zeolite and traditional fertilizers on lettuce. treatments  of 100, 75, 50 and 25% of the recommended dose of common N fertilizer and 100, 75, 50 and 25 ml of 1000 ppm Nano N solution were added alone or in combination with the traditional fertilizers to lettuce plants. Vegetative growth and yield characters were recorded. The obtained results indicated that the application of N-Nano resulted in significantly higher vegetation growth parameters such as plant fresh weight (PFW), shoot fresh weight (SFW), plant length (PL), leaf area (LA) and plant dry weight. The partial replacement of common N fertilizers by additional of Nano fertilizers to lettuce plants production could be a useful way to save the amount of common N fertilizers and enhancement of plant growth and increasing nutrients uptake by plants and to avoid nitrate leaching especially under sandy soils and consequently reducing pollution problems.