The study aims to investigate the effects of diets containing two levels of Ziziphus spina-Christi leaves, choline, and their combinations on nutritional evaluation, some biochemical analysis, and histopathological examination in the kidneys of rats suffering from acute liver disease. Forty-eight male albino rats were used . The rats were divided into two main groups: The first main group of six rats was fed a basal diet (as a negative control group). The second main group (42 rats) was injected with CCl4 in paraffin oil (50% v/v, 4 ml/kg) by subcutaneous injection to induce acute damage in the liver. The rats in the second main group were divided into7 subgroups (6 rats each) as follows: Subgroup (1): fed on a basal diet (BD) only as a control positive group (+ve). Subgroups 2 and 3 were fed diets containing 1% and 2% choline chloride, respectively. Subgroups 4 and 5 were fed diets containing 5% and 7.5% Zizyphus , respectively. Subgroups 6 and 7 were fed diets containing the combination of choline chloride and Zizyphus (1% choline chloride and 5% Zizyphus ) and (2% choline chloride and 7.5% Zizyphus), respectively. The results indicated that injected rats with CCl4 increased serum glucose, uric acid, urea nitrogen, creatinine, cholesterol, triglyceride, LDL-cholesterol and VLDL-cholesterol, while decreasing feed intake, serum HDL-cholesterol, as compared to non-injected rats. Conclusion: Ziziphus spina-Christi leaves, choline, and their combinations can be used to reduce the side effects of acute liver diseases.