The potential efficacy of two Egyptian scorpion species venoms, Leiurus quinquestratus and Androctonus bicolor was assessed in relation to hematological and biochemical parameters during the stages of chemically induced rat colon carcinogenesis. Fifty-five, 6-7-week-old male Sprague-Dawley rats weighing 120-125 gram were randomly divided into four groups: As a normal control, group 1 (10 rats) injected subcutaneous (s.c.) and intraperitoneal (i.p.) with saline only. From week 1 to week 4, groups 2, 3, and 4 received 1,2-dimethylhydrazine (40mg/kg/bw) weekly through s.c. injections. Groups 3 and 4 (15 rats per group) received i.p. injections of 1/20 of LD₅₀ from either L. quinquestratus (LQV) or A. bicolor (ABV) venoms from week 5 until the end of the experiment after 16 weeks. Rats were sacrificed following a 16-week experiment. Plasma and sera were collected from each rat's abdominal aorta. Significant alterations were observed in the hematological and biochemical liver and kidney parameters, in rats in treated groups administered (LQV) or (ABV) venoms. To sum up, the use of venoms isolated from L. quinquestratus or A. bicolor enhanced biochemical and hematological parameters during the colon carcinogenesis process.