Here in this work, some newly Schiff bases based on pyrazole moiety were synthesized through condensation reaction between pyrazole aldehyde (1) and some aromatic amines (2a-h). p-methyl aniline, m-methyl aniline, p-chloro aniline, m-chloro aniline, p-bromo aniline, m-nitro aniline, α-naphthyl amine and β-naphthyl amine were used as aromatic amines. The products of Schiff bases (3a-h) were obtained in good to high yields. Elemental analysis, FT-IR and 1H-NMR spectroscopy were used to characterize the structure of the prepared Schiff bases (3a-h). The characteristic peak for proton of pyrazole ring was appeared in the range of (8.5 – 8.57 ppm) in all prepared Schiff bases which confirm the formation of bonding between pyrazole aldehyde and different aromatic amines. The synthesized Schiff bases showed good antitumor activity based on molecular docking study which support that the modified Schiff bases can be employed as a feasible starting point for new reducing agents into therapeutic formulations.