Helicobacter pylori infection can cause chronic inflammation and is linked to changes in body mass index (BMI, kg/m2). This study evaluates the association between H. pylori infection and overweight/obesity syndrome. The study was made to estimate the relation of H. pylori and obesity with adipocytokines Leptin and Adiponectin. Clear evidence indicates that Leptin hormone and Adiponectin hormone, contribute substantially to the improvement of this disease: H pylori and Obesity. This study evaluates the relationship between serum Leptin hormone, adiponectin hormone and infection with Helicobacter pylori in patients with obesity. A total of 50 healthy subjects and 100 patients were included in the research. Infected with H. Pylori in addition to non- infected with H. pylori obese patients There were 50 obese patients without infection of H. Pylori (group 2) in addition to 50 obese patients with infection of H. Pylori (group 3) with significant change in serum Leptin level and Adiponectin level also in comparison with 50 healthy control (group3). There was a rise in the levels of serum triglyceride and cholesterol and low HDL-c in patient groups as well as an increase in the BMI compared to healthy group.