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Insights into Gut Microbiota and Pancreatic Cancer: A Review

Article

Last updated: 28 Dec 2024

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Subjects

-

Tags

Pharmaceutical Sciences

Abstract

Pancreatic cancer is one of the major causes of cancer-related death worldwide and has a poor prognosis as pancreatic cancer usually shows little or no symptoms until it has advanced and spread. Therefore, most cases (up to 80 percent) are diagnosed at later, more difficult-to-treat stages. Currently, treatment relies on surgical resection and adjuvant therapies. Recent advances in biomedical research have highlighted the potential role of gut microbiota in the pathogenesis and progression of various cancers, including pancreatic cancer. The gut microbiota plays a crucial role in metabolism and immunomodulation. Emerging evidence suggests that the gut microbiota influences the metabolism of chemotherapeutic drugs and the tumor microenvironment, potentially affecting the efficacy of chemotherapy and immunotherapy for pancreatic cancer. In this review, we discuss the key connections between pancreatic cancer, the gut microbiota, and therapeutic effectiveness. We also highlight the promising potential of modifying the gut microbiota to enhance clinical outcomes for pancreatic cancer.



Keywords: Gut microbiota; Pancreatic cancer; Chemotherapy; Immunotherapy

DOI

10.21608/dusj.2024.294000.1070

Keywords

gut microbiota, Pancreatic cancer, Chemotherapy, Immunotherapy

Authors

First Name

Rasha

Last Name

El Morsi

MiddleName

Medhat

Affiliation

Department of Microbiology & Immunology, Faculty of Pharmacy, Delta University For science and Technology, Gamsa, Egypt

Email

rashamedhat07@gmail.com

City

-

Orcid

-

First Name

Sohila H.

Last Name

AL Shafie

MiddleName

-

Affiliation

1Students, Faculty of Pharmacy, Delta University for Science and Technology, Gamsa, Egypt

Email

sohilahisham61@gmail.com

City

-

Orcid

-

First Name

Sara

Last Name

A. El Ashry

MiddleName

-

Affiliation

1Students, Faculty of Pharmacy, Delta University for Science and Technology, Gamsa, Egypt

Email

sara1456ashry@gmail.com

City

-

Orcid

-

First Name

Sara S

Last Name

. EL Naggar

MiddleName

-

Affiliation

1Students, Faculty of Pharmacy, Delta University for Science and Technology, Gamsa, Egypt

Email

saraelmagart345@gmail.com

City

-

Orcid

-

First Name

Sara E

Last Name

Bedair

MiddleName

-

Affiliation

1Students, Faculty of Pharmacy, Delta University for Science and Technology, Gamsa, Egypt

Email

sarabedair22@gmail.com

City

-

Orcid

-

First Name

Shrouq N

Last Name

Dehina

MiddleName

-

Affiliation

1Students, Faculty of Pharmacy, Delta University for Science and Technology, Gamsa, Egypt

Email

shrouqnasr999@gmail.com

City

-

Orcid

-

First Name

Shokran A.

Last Name

Kamal

MiddleName

-

Affiliation

1Students, Faculty of Pharmacy, Delta University for Science and Technology, Gamsa, Egypt

Email

shokarakamal77@gmail.com

City

-

Orcid

-

First Name

Mai H.

Last Name

El Hadidy

MiddleName

-

Affiliation

1Students, Faculty of Pharmacy, Delta University for Science and Technology, Gamsa, Egypt

Email

maielhadidy5@gmail.com

City

-

Orcid

-

First Name

Menna H.

Last Name

El Henidy

MiddleName

-

Affiliation

1Students, Faculty of Pharmacy, Delta University for Science and Technology, Gamsa, Egypt

Email

menna.elhenidy52@gmail.com

City

-

Orcid

-

First Name

Nada A.

Last Name

El Nagdy

MiddleName

-

Affiliation

1Students, Faculty of Pharmacy, Delta University for Science and Technology, Gamsa, Egypt

Email

n.elnagdy@gmail.com

City

-

Orcid

-

First Name

Yasmin H.

Last Name

El Hawary

MiddleName

-

Affiliation

1Students, Faculty of Pharmacy, Delta University for Science and Technology, Gamsa, Egypt

Email

yasminhesham77@gmail.com

City

-

Orcid

-

First Name

Hana A.

Last Name

Gomaa

MiddleName

-

Affiliation

1Students, Faculty of Pharmacy, Delta University for Science and Technology, Gamsa, Egypt

Email

hannah.gomaa.30@gmail.com

City

-

Orcid

-

First Name

Reham M.

Last Name

Khalifa

MiddleName

-

Affiliation

1Students, Faculty of Pharmacy, Delta University for Science and Technology, Gamsa, Egypt

Email

rehamkhalifa09@gmail.com

City

-

Orcid

-

First Name

Esraa M.

Last Name

Yosef

MiddleName

-

Affiliation

1Students, Faculty of Pharmacy, Delta University for Science and Technology, Gamsa, Egypt

Email

israa.mostafa27@gmail.com

City

-

Orcid

-

First Name

Reham

Last Name

Goda

MiddleName

M.

Affiliation

Department of Microbiology & Immunology, Faculty of Pharmacy, Delta University For science and Technology, Gamsa, Egypt

Email

reham677magedy@gmail.com

City

-

Orcid

-

First Name

Heba

Last Name

Ramadan

MiddleName

Adel

Affiliation

Department of Microbiology & Immunology, Faculty of Pharmacy, Delta University For science and Technology, Gamsa, Egypt

Email

hebaaa.aadel@gmail.com

City

-

Orcid

-

First Name

Wafaa

Last Name

Soliman

MiddleName

E.

Affiliation

2Department of Microbiology & Immunology, Faculty of Pharmacy, Delta University For science and Technology, Gamsa, Egypt 5Department of Biomedical Sciences, College of Clinical Pharmacy, King Faisal University, AL AHSA 31982, Kingdom

Email

wafaa.soliman@deltauniv.edu.eg

City

-

Orcid

-

First Name

Mohamed

Last Name

Abd El-Salam

MiddleName

-

Affiliation

3Department of Pharmacognosy, Faculty of pharmacy, Delta University for Science and Technology, Gamasa 11152, Egypt

Email

moha.absalam@gmail.com

City

-

Orcid

-

First Name

Lamiaa

Last Name

Al-Madboly

MiddleName

-

Affiliation

4Department of Microbiology & Immunology, Faculty of Pharmacy, Tanta University, Tanta, Egypt

Email

lamia.youssif@pharm.tanta.ed

City

-

Orcid

-

Volume

7

Article Issue

2

Related Issue

52436

Issue Date

2024-09-01

Receive Date

2024-05-30

Publish Date

2024-09-01

Page Start

1

Page End

16

Print ISSN

2636-3046

Online ISSN

2636-3054

Article File

DUSJ_Volume 7_Issue 2_Pages 1-16.pdf

PDF . 544.1kB

Link

https://dusj.journals.ekb.eg/article_399748.html

Detail API

https://dusj.journals.ekb.eg/service?article_code=399748

Order

399,748

Type

Review articles

Type Code

1,770

Publication Type

Journal

Publication Title

Delta University Scientific Journal

Publication Link

https://dusj.journals.ekb.eg/

MainTitle

Insights into Gut Microbiota and Pancreatic Cancer: A Review

Details

Type

Article

Created At

28 Dec 2024