Fibromyalgia (FM) is a clinical syndrome commonly observed in daily medical practice and its etiology is still unclear. FM occurs at any age and is more common in females. Despite the good prognosis for this painful condition, patients with FM consume huge amounts of financial resources in public or private health care both for treatment and diagnostic investigation. Purpose: the aim of this review is to identify different treatment approaches for fibromyalgia and to determine the effect of these approaches on pain, tender point number, sleep problems and health related quality of life. Methods: the published researches that studied FM since 1990 were assessed according to CONSORT checklist. Fair to Good quality researches were included, while low quality researches were excluded. Result: Aerobic training is the important type of exercise therapy. Progression of the exercises was recommended minimize pain. Electrotherapy modalities as well as Alternative/complementary therapies could reduce pain as well. Conclusion: treatment of FM should be multidisciplinary, individualized, depending on active participation of the patient, and based on combined pharmacological and non-pharmacological modalities.