Introduction: The COVID-19 pandemic has necessitated the rapid development and deployment of vaccines to curb the spread of the virus. Among the various vaccines developed, AstraZeneca, Sinovac, Johnson & Johnson, and Moderna have been widely administered globally.
Purpose : The primary objective is to analyze OCT angiography findings before and after COVID-19 vaccination, focusing on parameters such as macular thickness, RNFL thickness, GCC thickness, SVD & DVD , FAZ area, subfoveal choroidal thickness and peri-papillary area vessel density.
Subjects and Methods: This prospective cohort study will include 88 healthy vaccinated individuals recruited from Fayoum University Hospital and Misr University for Science and Technology Hospital in Egypt. Participants will undergo comprehensive ophthalmological examinations, OCT imaging, and OCT angiography analysis. Statistical analysis will be conducted using SPSS, including Chi-squared tests, Fisher tests, and independent sample t-tests.
Results: Preliminary results indicate subtle changes in retinal and ocular parameters post-vaccination, with variations observed among the vaccine groups. Pairwise comparisons and correlations show statistically significant differences and strong positive correlations between pre- and post-vaccination measurements.
Conclusion: The study provides valuable insights into OCT angiography changes following COVID-19 vaccination, highlighting potential microvascular alterations in the retinal and choroidal layers. These findings contribute to our understanding of ocular health implications associated with different COVID-19 vaccines.