Propose: This study compared the efficacy of external dacryocystorhinostomy with and without intraoperative mitomycin-C in patients presenting with chronic dacryocystitis secondary to the nasolacrimal duct obstruction.
Patients and methods: This study included 40 patients with chronic dacryocystitis who underwent external dacryocystrhinostomy and were randomly divided into two equal groups using computer generated random tables according to the surgical technique used. Patients seeking external DCR were subdivided into 2groups: Group A included 20patients who were operated with mitomycin-C, and Group B included 20patients who were operated without mitomycin-C. Post operative care with systemic antibiotics, eye drops with antibiotic, nasal decongest and drops, follow up visits will be done at 1,3weeks; 1 and 3months. Successful outcomes were defined by resolution of symptoms, DDT and by probing and irrigation.
Results: Our study results have revealed that there was no statistically significant difference between both groups regarding age, gender, laterality of lesions or preoperative symptoms. Regarding patency of nasolacrimal duct, there was a significant difference between two studied group, the success rate was higher in group(A) than group(B). Regarding postoperative complications, wound infection was found in 1 case in group(1) and 5cases in group(2). At the end of 3months follow up, there was a significant difference between the two studied groups regarding Patency.
Conclusion: Applying 0.2mg/ml mitomycin-C for 10minutes intraoperatively in external DCR provided much better surgical results regarding symptoms relief, the lacrimal drainage system patency and increases the chances of success of external DCR surgery, than conventional external DCR without mitomycin-C.