Failure of postnatal closure of ductus arteriosus (DA) in preterm infants may lead to clinical symptoms of
an open-angle DA (PDA) that are hemodynamically significant and need treatment. As a result of the
decreased blood supply to essential organs and the resulting alterations in cerebral blood flow, brain damage
is possible. Using cranial Doppler ultrasonography, this research was able to measure the cerebral
hemodynamic consequences of PDA and its correlation to the prognosis. After 24 hours, clinical parameters
and transcranial Doppler of the anterior cerebral artery were assessed and divided into two groups: HS PDA
(hemorodynamically significant) and HIS PDA (hemorodynamically insignificant) based on clinical
deterioration after 72 hours. 71 preterm neonates were included in the study. There is a high correlation
between the resistive index (RI) and the clinical worsening of hemodynamically significant patients. Aside
from clinical measures and echocardiography, the results of this research show that the trans-cranial Doppler
is an effective bedside technique for predicting hemodynamically significant PDA in preterm infants before
clinical parameters deteriorate and avoids further clinical deterioration. For preterm infants, we suggest
cranial Doppler scanning as soon as possible