Background: Many different therapies are available for patients with numerous warts. The majority of these treatments target the diseased tissue directly, but sometimes the amount of cellular damage is insufficient to release the cytokines that kill the latent virus. In such cases, patients seek for other treatments. In this article, we will have a look at the results of treating cutaneous warts with intralesional polidocanol and intralesional combination furosemide and digoxin. Final thoughts: Treatment of cutaneous warts with injections of Polidocanol and a combination of intralesional furosemide and digoxin seems to be a safe, highly successful, and adverse effect-minimizing option. Many different therapies are available for patients with numerous warts. The majority of these treatments target the diseased tissue directly, but sometimes the amount of cellular damage is insufficient to release the cytokines that kill the latent virus. In such cases, patients seek for other treatments. In this article, we will have a look at the results of treating cutaneous warts with intralesional polidocanol and intralesional combination furosemide and digoxin. Final thoughts: Treatment of cutaneous warts with injections of Polidocanol and a combination of intralesional furosemide and digoxin seems to be a safe, highly successful, and adverse effect-minimizing option.