Background: Anaesthetic adjuvants have the ability to significantly improve patient safety and satisfaction when administered with local anaesthetics. Technological progress necessitates the ongoing search for novel agents that may extend the duration and effectiveness of nerve blocks. In particular, opioids have shown promise as adjuvants in the subarachnoid and epidural areas, where they have been the subject of much research. In addition to prolonging the duration of analgesia after surgery, they also enhance the quality of analgesia administered during the procedure itself. Research has shown that dexmedetomidine is an effective nerve block adjuvant, surpassing clonidine. It lessens the need for more analgesics by extending the duration of sensory and motor blockage. Research has shown that epinephrine may prolong the effects of sensory nerve blockage and postpone the systemic absorption of local anaesthetics. This enhances patient safety by reducing the danger of anesthetic toxicity. The use of dexamethasone in neuraxial blocks has been shown to be effective in extending the duration of analgesia, whereas in peripheral nerve blocks it has been demonstrated to prolong nerve blockade. On the other hand, nerve blocks should not routinely utilize all adjuvants.