Background: Approximately 5% of the population experiences hemorrhoids. Grade III and IV hemorrhoids that cause symptoms, as well as those for whom medicinal therapy has not been successful or when other complications such anal fissures or ulcers are present, need surgical intervention. Hemorrhoids may be treated using a variety of procedures, including Milligane Morgan's open hemorrhoidectomy and Ferguson's closed hemorrhoidectomy. There are a number of new tools and techniques that may make the surgery easier and reduce postoperative pain for patients. Comparing stapled hemorrhoidopexy with harmonic scalpel hemorrhoidectomy was the primary goal of this research. Methods At Banha, researchers undertook a randomised controlled experiment on one hundred patients suffering from hemorrhoidal illness of Grade III or IV. A harmonic scalpel hemorrhoidectomy was performed on Group 2, whereas stapled hemorrhoidopexy was performed on Group 1 patients. The participants were randomly allocated to either group. Laboratory testing, clinical and rectal exams, and medical histories were all part of the data collecting process. At one week, three months, and six months after surgery, the two groups were compared with respect to postoperative discomfort, complications, recovery time, and recurrence rates. Results When comparing Group 1 to Group 2, there was a substantial decrease in postoperative discomfort, hospital stay, and recovery time[P < 0.001]. There was no statistically significant difference between the groups with regard to postoperative bleeding, infection, or recurrence. Conclusion: In comparison to harmonic scalpel hemorrhoidectomy, stapled hemorrhoidopexy had a lower risk of complications and a shorter recovery time for patients.