Context: Onychomycosis is among the most prevalent fungal infections, accounting for as much as 50% of nail illnesses. Even though there are systemic and topical antifungal medications available, treatment hurdles such inadequate penetration, drug resistance, and adverse effects still exist. A targeted and non-invasive approach to treating onychomycosis that has become resistant to other treatments is photodynamic therapy (PDT).. It uses light-activated photosensitizers to produce reactive oxygen species. Objective: To what extent is photodynamic therapy safe and effective in treating onychomycosis? That is the goal of this narrative evaluation. Methods: In order to determine the effectiveness, safety, and mechanisms of PDT in treating onychomycosis, a systematic literature review was performed. The study also looked at how well PDT may work to improve patient compliance and decrease the development of fungal biofilms. In summary: As an alternative to conventional antifungal treatments, photodynamic therapy shows promise in the treatment of onychomycosis. Fewer side effects, less likelihood of medication resistance, and increased antifungal efficacy when combined with other treatments are some of its benefits. For patients who are resistant to other treatments or have side effects from them, PDT is a good alternative because of its safety record and its capacity to target fungal biofilms.