Background: The overproduction of keratinocytes is a hallmark of the inflammatory skin condition known as psoriasis. The etiology of psoriasis is complex and includes both hereditary and environmental variables, including cigarette smoking, drug use, emotional and mental stress, trauma, and infections. Mucosal membranes are protected against microbes by a class of antimicrobial peptides called human beta-defensins (hBDs, −1, 2, 3). In addition to their antibacterial properties, they have other functions, such as cell activation, proliferation, migration, differentiation, angiogenesis, wound healing, and modulation of cytokine/chemokine production. The purpose of this article is to examine the relationship between the severity of psoriatic illness and the levels of human β-defensins in the serum. In conclusion, psoriasis may be influenced by serum levels of beta-defensin-2 and beta-defensin-3. Its potential as a biomarker of disease severity is shown by the association between human beta-defensin-2 and beta-defensin-3 levels and the severity of psoriasis.Background: The overproduction of keratinocytes is a hallmark of the inflammatory skin condition known as psoriasis.