Background: Recent developments in the study of vitiligo have shown the presence of several susceptibility genes for the condition on separate chromosomes. The purpose of this investigation is to examine if NLRP3 and IL-1β have a function in vitiligo sufferers. Data Sources: The involvement of NLRP3 and IL-1β in vitiligo up till 2024 was determined by searching and reading Medline databases (Pub Med and Medscape). Study Selection: Each study was carefully reviewed by experts in the field to ensure its inclusion. They were considered for inclusion if they met the following requirements: 1. The publication is in English. 2. Articles published in publications that undergo a rigorous peer review process.3. Talk about how NLRP3 and IL-1β are involved in vitiligo sufferers. Research Extraction: Studies were omitted from the data set if they failed to meet the inclusion criteria. The study's quality was evaluated based on a number of factors, such as the following: the availability of acceptable controls, sufficient information, clearly defined evaluation measures, and whether or not ethical permission was obtained. For our concerned research outcomes, data were independently extracted from all qualifying studies utilizing a data collecting form. Results: It is reasonable to assume that NLRP3 and IL-1β in vitiligo patients could contribute to the condition's development and severity.