Background The skin and joints may be affected by the chronic inflammatory illness known as psoriasis. It may show up as different phenotypes. A systemic inflammatory disorder, it damages many organs and tissues over time because to the persistent activation of the immune system and the increased production of pro-inflammatory cytokines by immune-related cells. Rheumatological, cardiovascular, and mental problems are among the many comorbidities linked to it. The role of genes in the development of psoriasis should be carefully considered.Background The skin and joints may be affected by the chronic inflammatory illness known as psoriasis. It may show up as different phenotypes. A systemic inflammatory disorder, it damages many organs and tissues over time because to the persistent activation of the immune system and the increased production of pro-inflammatory cytokines by immune-related cells. Rheumatological, cardiovascular, and mental problems are among the many comorbidities linked to it. The role of genes in the development of psoriasis should be carefully considered.