Background: Neonatal infant mortality is defined as the loss of a neonate between the ages of 0 and 27 days. The first week of a baby's existence (between 0 and 6 days old) is the most dangerous time for their health. Specifically, this research set out to identify the factors that contribute to the high incidence of infant death in Qalyubiya Governorate's hospitals. Methods: All newborns (≤28 days) admitted to the NICU were included in this prospective cross-sectional study. There were 973 in the "alive" group and 164 in the "died" group. End result: Tragically, 86% of patients hospitalized to the neonatal intensive care unit (NICU) at Benha University Hospital who were 28 weeks or younger at the time of admission passed away. In the NICU at Benha University Hospital, 9.3% of patients hospitalized between 32 and 36 weeks of gestation died. All patients hospitalized to the neonatal intensive care unit at Benha Health Insurance Hospital who were between the ages of 28 and 32 weeks gestation perished, whereas all patients treated with a gestational age of 36 weeks or more showed improvement. At Benha Specialized Children Hospital NICU, every single kid admitted at a gestational age of 28 weeks or less perished. With a gestational age more than 36 weeks, 6% of children admitted to the neonatal intensive care unit at Benha Specialized Children's Hospital died. 60% of infants hospitalized to the neonatal intensive care unit at Toukh Hospital died between 28 and 32 weeks of gestation.