Prior to initiating HFNC support, the doctor will ascertain the gas temperature, FiO2 percentage, and flow rate. Gas temperature is usually adjusted 1oC to 2oC below body temperature for comfort, while patient physiology should guide the selection of FiO2 and its modification to reach the aim of peripheral capillary oxygen saturation (SpO2). The ideal starting gas flow rate is not universally agreed upon, however a flow dosage depending on weight is favored. For newborns to get respiratory support, the recommended flow rates range from 0.5 to 1 L/kg/min. Flow rates of up to 2 L/kg/min effectively reduce intrathoracic pressure fluctuations induced by effort of breathing and are considered optimal. Clinical results are not improved by flows greater than 2 L/kg/min. Efficacious but noninvasive Individuals suffering from neuromuscular weakness, extrathoracic airway blockage, obstructive or restrictive lung disease, and other conditions have greatly benefited from the use of noninvasive positive pressure ventilation (NIPPV) techniques including CPAP and BiPAP.