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368967

Analgesic Efficacy of IV Dexamethasone vs Intrathecal Dexamethasone as an Adjuvant to Spinal Anesthesia in Lower Abdominal Surgeries

Article

Last updated: 05 Jan 2025

Subjects

-

Tags

Medical and Health Science.

Abstract

Background: Dexamethasone, an adjuvant to spinal anesthesia, has been explored for its potential to prolong sensory block duration. However, the comparative efficacy of intravenous (IV) versus intrathecal administration remains unclear. Objective: To compare the analgesic efficacy and duration of sensory block between IV dexamethasone and intrathecal dexamethasone as adjuvants to spinal anesthesia in lower abdominal surgeries. Patients and Methods: This interventional clinical trial included 90 patients undergoing lower abdominal surgeries, randomized into two equal groups: Group IT (intrathecal dexamethasone 4 mg + bupivacaine) and Group IV (IV dexamethasone 8 mg + bupivacaine). The primary outcome was the duration of sensory block. Secondary outcomes included time to first rescue analgesia, total rescue analgesia, VAS scores, and incidence of complications. Results: The onset of sensory block was marginally faster in Group IV (28 ± 4 minutes) compared to Group IT (29 ± 3 minutes) (P = 0.046). However, Group IT demonstrated a significantly longer duration of sensory block (177 ± 17 minutes) versus Group IV (120 ± 16 minutes) (P < 0.001). Group IT also exhibited a longer time to first rescue analgesia (340 ± 27 minutes vs. 255 ± 27 minutes, P < 0.001) and lower VAS scores at 2, 4, and 24 hours postoperatively (P < 0.001). Conclusion: Intrathecal dexamethasone significantly prolongs the duration of sensory block and analgesia compared to IV dexamethasone when used as an adjuvant to spinal anesthesia in lower abdominal surgeries. Both routes of administration were comparable in terms of safety.

DOI

10.21608/bjas.2024.303258.1448

Keywords

dexamethasone, Spinal anesthesia, Sensory block, Analgesia, Lower abdominal surgery

Authors

First Name

Ahmed

Last Name

Dawood

MiddleName

Abo-Elghet

Affiliation

Anesthesia and Intensive Care Department, Faculty of Medicine, Benha University, Benha, Egypt.

Email

ahmed.aboelgheit@yahoo.com

City

-

Orcid

-

First Name

Saad

Last Name

Saad

MiddleName

Ibrahim

Affiliation

Anesthesia and Intensive Care Department, Faculty of Medicine, Benha University, Benha, Egypt.

Email

saadibrahim_7@yahoo.com

City

-

Orcid

-

First Name

Anas

Last Name

Fetian

MiddleName

Ibrahim Taha

Affiliation

Anesthesia and Intensive Care Department, Faculty of Medicine, Benha University, Benha, Egypt.

Email

anaswm1@gmail.com

City

-

Orcid

-

Volume

9

Article Issue

7

Related Issue

49060

Issue Date

2024-07-01

Receive Date

2024-07-01

Publish Date

2024-07-29

Page Start

11

Page End

16

Print ISSN

2356-9751

Online ISSN

2356-976X

Link

https://bjas.journals.ekb.eg/article_368967.html

Detail API

https://bjas.journals.ekb.eg/service?article_code=368967

Order

8

Type

Original Research Papers

Type Code

1,647

Publication Type

Journal

Publication Title

Benha Journal of Applied Sciences

Publication Link

https://bjas.journals.ekb.eg/

MainTitle

Analgesic Efficacy of IV Dexamethasone vs Intrathecal Dexamethasone as an Adjuvant to Spinal Anesthesia in Lower Abdominal Surgeries

Details

Type

Article

Created At

28 Dec 2024