Background: Premature Hair graying is a medical disease for which the causes and treatments are still up for debate. The etiopathogenesis of premature graying is believed to include many variables. Albumin that has had its N-terminal altered as a result of ischemia is known as ischemia-modified albumin. Some researchers believe that hormone imbalances and other biological factors are the root of erectile dysfunction. Further, the importance of oxidative stress in the development of erectile dysfunction was uncovered. The purpose of this paper is to examine the correlation between vasogenic erectile dysfunction and the amount of serum ischemia modified albumin in individuals who have premature hair thinning. Final thoughts: Possible involvement of serum IMA in the onset of premature hair graying. Its serum levels may also serve as independent indicators of vulnerability to, and severity of, premature hair graying. Those who took PGH and those who did not have statistically significant differences in erectile dysfunction. The vasculogenic kind of erectile dysfunction may be associated with IMA. Erectile dysfunction may be more common in those with polycystic ovary syndrome (PGH).