Background: Vitiligo is recognized as a systemic depigmenting skin illness with a complex etiology. Its effects extend beyond the skin and into the body, causing metabolic irregularities such glucose and lipid abnormalities. Many nations throughout the globe are experiencing pandemic levels of obesity. Excess white adipose tissue causes systemic and chronic inflammation since it is an active endocrine organ. Adipocytes and macrophages, which are cells of adipose tissue, release adipocytokines, which induce and sustain this inflammation. Both vaspin and omentin are adipocytokines that have just recently been identified. The purpose of this piece is to provide a synopsis of the function of vaspin proteins in psoriasis and vitiligo. It provides a summary of the vaspin function and how it relates to the severity of vitiligo in patients. In summary: Vaspin, a serine protease inhibitor produced from visceral adipose tissue, has several functions in skin disorders. Changes in its expression levels may help with diagnosis and prognosis in vitiligo and psoriasis.