Background: Acne Acne vulgaris (AV) is a chronic inflammatory illness affecting the pilosebaceous unit. It is mostly caused by hyperkeratinization of the follicle, inflammation, bacterial colonisation, and increased sebum production. Reviewing the aetiology and pathophysiology of acne vulgaris and discussing the significance of cutibacterium acnes strains is the objective of this article. Sources of Information: Studies examining the aetiology, pathophysiology, and function of cutibacterium acnes strains up to the year 2024 were located via a search and examination of the Medline databases (Pub Med and Medscape). Study Selection: Each study was carefully reviewed by experts in the field to ensure its inclusion. They were considered for inclusion if they met the following requirements: 1. The language of writing and publication is English. Second, they are published in publications that undergo a peer review process.Discuss the involvement of different strains of the bacteria known as cutibacterium acnes and review the aetiology and development of acne vulgaris. When extracting data, studies were discarded if they did not meet the inclusion criteria. Ethical permission, clear eligibility criteria, suitable controls, sufficient information, and well-defined evaluation measures were all variables in determining the study's quality. For our concerned research outcomes, data were independently extracted from all qualifying studies utilising a data collecting form. Final thoughts: A variety of factors contribute to the complicated pathophysiology of AV, a skin disease that begins with the breakdown of the pilosebaceous unit. Acne vulgaris (AV) pathology is characterised by four traditional principles based on the pilosebaceous unit: