Background: Systemic lupus erythematosus is a multisystem disease associated with
Background: Systemic lupus erythematosus (SLE) is a multisystem disease associated with
significant morbidity and mortality. Safety measures programs are the activities or strategies that are directed towards raising the general level of health and patients' well-being.  Aim of study: This study aimed to evaluate the effect of safety measures program on Systemic lupus erythematosus patients' outcome. Design: Quasi-experimental research design was utilized to conduct the aim of this study. Setting: The study was conducted at Rheumatology out-patient clinic at Benha University Hospital in Qualubia Governorate. Sample: Purposive sample of adult patients with systemic lupus erythematosus who are attending at the previous mentioned setting. Tools: Five tools are used Tool I: Structure interviewing questionnaire. Tool II: Patients knowledge about safety measures, Tool III: Fatigue Severity Scale, Tool IV: patient-reported outcome (PRO) & Tool V: Safety measures activities regarding SLE. Results: There was a highly statistical significant differences regarding total knowledge about safety measures for SLE, fatigue level and total Lupus PRO between pre and post implementing the program (P-value < 0.001**). Conclusion: Implementation of safety measures program had a positive and significant effect on patients' knowledge level as well as reducing fatigue severity and improving total Lupus PRO three months post safety measures program were found. Recommendation: Implementing educational program for patients with systemic lupus erythematosus in order to enhance their health status and prevent complications.