Background: Helicobacter pylori infection is one of the most prevalent bacterial disorders worldwide, contributing to around 50% of all infections. Aim of study: was to assess the quality of life among patients with helicobacter pylori infection. Research Design: Descriptive research design was utilized in conducting this study. Setting: The Benha University Hospital in Benha City's Medical Outpatient Clinics served as the study's location. Sample: A simple random sample was employed. Which included 288 patients. Tools.Two tools were utilized. Tool I: A structured interviewing questionnaire: to assess patient's socio demographic characteristics, medical history, knowledge about helicobacter pylori infection and reported practices for preventing complications of helicobacter pylori infection. Tool II: A scale for determining the quality of Life of helicobacter pylori-infected patients. Results:39.2% of studied patients ‘age ranged between 50 to less than 60 years old, 27.1 % suffered from chronic diseases, 92.4 % of them had diagnosed with H. pylori infection from less than one year, 45.8% had average knowledge level about helicobacter pylori infection, 55.6% exhibited unsatisfactory practices level for preventing complication of helicobacter pylori infection, 32.3 % of them had diminished quality of Life level. Conclusion: less than one fifth of the patients had good knowledge or understanding of helicobacter pylori, while over than half of them had satisfactory levels of practice about the infection. Furthermore, less than half of them had an average quality of Life. Strong positive relations were observed between the total knowledge score, total reported practices score, and overall quality of Life score of the patients under research. Recommendation: develop health educational programs for helicobacter pylori infection that help patients to improve and update the most current knowledge, practices, and quality of Life about helicobacter pylori infection. Background: Helicobacter pylori infection is one of the most prevalent bacterial disorders worldwide, contributing to around 50% of all infections. Aim of study: The goal of this investigation was to ascertain the quality of life (QoL) for helicobacter pylori infected patients. Research Design: Descriptive research design was utilized in conducting the research. Setting: The Benha University Hospital in Benha City's Medical Outpatient Clinics served as the study's location. Sample: In this investigation, a basic random sample was employed. There were 288 patients in it. Tools. There were two tools utilized. Tool I: The following was evaluated using a structured interview questionnaire: (A) sociodemographic characteristics of H. pylori-infected patients who were the subjects of the study ; (B) medical history of H. pylori-infected patients who were the subjects of the study . Results: 39.2 % of patients under study were age varied among 50 to being below 60 years old, 27.1 % of patients under study were suffered from chronic diseases, 92.4 % of the studied patients had diagnosed with H. pylori infection from less than one year 45.8% of patients Conclusion: A minority of the patients analyzed possessed inadequate knowledge or understanding of helicobacter pylori, while over 50% reported unacceptable levels of practice about the infection. Recommendation: Construct health education initiatives pertaining to H. Pylori infection that assist individuals in enhancing and being current with regard to the most recent information, behaviors, and QoL concerning this pathogen.