Traditional medicine across all traditions has relied on plant remedies since ancient times. Traditional medicine relies on a wide variety of herbs and antibacterial compounds found in plants for dental care. Antimicrobial activity against three pathogenic bacteria—Staphlococcus aureus, Acinetobacter baumannii complex, and Klebsiella pneumoniae—was evaluated by assaying extracts of Thymus Vulgaris and Cinnamomum camphora. The bacteria were detected biochemically and using the VITEK2 system. Antibiotic susceptibility testing revealed that all three isolates were resistant to the twenty-plus antibiotics tested. In vitro investigations of five Egyptian plant extracts of Anastatica hierochuntica L , Thymus vulgaris , Olea europaea leaf and costus sasurrea, Cinnamomum camphora showed that aqueous Thymus Vulgaris and aqueous Cinnamomum camphora extract could exhibit an antibacterial activity against human pathogenic isolates and inhibition zones of 20.0±1.5 ,3.0±0and 20.0 ±1 mm were observed when Thymus Vulgaris extract applied against the above-mentioned bacteria, while the inhibition zones of 15.0±0.577,2±0.577 and 18.0±0.577 mm were observed by Cinnamomum camphora extract while aqueous plant extracts of Anastatica hierochuntica L, Olea europaea leaf and Costus sasurrea don´t have any effect on the bacterial isolates .Thymus vulgaris, Cinnamomum camphora, Staphylococcus aureus, Acinetobacter baumannii complex, Klebsiella pneumoniae