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354747

Chitosan-doped gold nanoparticles with potent and selective activity against diabetes mellitus

Article

Last updated: 28 Dec 2024

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Subjects

-

Tags

Applied and Basic Science.

Abstract

Background: Diabetes Mellitus (DM) poses a significant global health challenge, with rising prevalence and associated complications. Despite available treatments, the search for safer and more effective options continues. This study investigates the potential of chitosan-doped gold nanoparticles (AuNPs-chito) as a novel therapeutic approach for DM. Chitosan shows promise as a flexible biomolecule for the management of several pathophysiological problems linked to diabetes mellitus (DM) because of its dual roles as an antidiabetic agent and medication carrier
Methods: Streptozotocin-induced diabetic rats were treated with AuNPs-chito, and various biochemical and histopathological parameters were assessed.
Results: Our data indicate that AuNPs-Chito administration led to significant improvements in blood glucose levels, lipid profiles, oxidative stress markers, and liver function compared to untreated diabetic rats. Histopathological examination revealed restoration of hepatic architecture in AuNPs-chito-treated rats.
Conclusion: These findings suggest that AuNPs-chito may offer a promising strategy for managing DM by mitigating oxidative stress and improving metabolic parameters.

DOI

10.21608/bjas.2024.270344.1334

Keywords

Gold nanoparticles, Chitosan, Diabetes mellitus, Hepatotoxicity, Oxidative Stress

Authors

First Name

Alaa

Last Name

.Elmetwalli

MiddleName

-

Affiliation

Department of Clinical Trial Research Unit and Drug Discovery, Egyptian Liver Research Institute and Hospital (ELRIAH), Mansoura, Egypt Microbiology Division, Higher Technological Institute of Applied Health Sciences, Egyptian Liver Research Institute and Hospital (ELRIAH), Mansoura, Egyp

Email

dr.prof2011@gmail.com

City

Mansoura

Orcid

0000-0001-5372-4297

First Name

Mervat

Last Name

. G. Hassan

MiddleName

-

Affiliation

Botany and Microbiology Department, Faculty of Science, Benha University, Benha, Egypt

Email

mervat.hassan@fsc.bu.edu.eg

City

Benha

Orcid

0000-0002-5481-921X

First Name

Fatma

Last Name

Ashraf

MiddleName

-

Affiliation

Botany and Microbiology Department, Faculty of Science, Benha University, Benha, Egypt

Email

fatmashrafbenhauni.egypt@gmail.com

City

-

Orcid

-

First Name

Mohamed

Last Name

. O. Abdel-Monem

MiddleName

-

Affiliation

Botany and Microbiology Department, Faculty of Science, Benha University, Benha, Egypt

Email

mohamedabdelmonem@benha.edu.eg

City

-

Orcid

-

First Name

Jihan

Last Name

Hassan

MiddleName

-

Affiliation

Department of Applied Medical Chemistry, Medical Research Institute, Alexandria University, Alexandria, Egypt

Email

jihanhassanalexuniv.heam@gmail.com

City

-

Orcid

-

Volume

9

Article Issue

3

Related Issue

46895

Issue Date

2024-03-01

Receive Date

2024-02-18

Publish Date

2024-03-01

Page Start

181

Page End

185

Print ISSN

2356-9751

Online ISSN

2356-976X

Article File

BJAS_Volume 9_Issue 3_Pages 181-185.pdf

PDF . 690.1kB

Link

https://bjas.journals.ekb.eg/article_354747.html

Detail API

https://bjas.journals.ekb.eg/service?article_code=354747

Order

23

Type

Original Research Papers

Type Code

1,647

Publication Type

Journal

Publication Title

Benha Journal of Applied Sciences

Publication Link

https://bjas.journals.ekb.eg/

MainTitle

Chitosan-doped gold nanoparticles with potent and selective activity against diabetes mellitus

Details

Type

Article

Created At

28 Dec 2024