Abstract Objectives: Investigating the role of the serum level of MicroRNA106b in psoriatic patients and its relation to disease severity.Background: MicroRNA106b has been shown to play a crucial role in the pathogenesis of several autoimmune diseases but was poorly investigated in patients with psoriasis.Data Sources: By searching and reviewing Medline databases (Pub Med and Medscape) and looking for studies that examined the possible role of MicroRNA106b in patients with psoriasis available till 2022. Study Selection: All studies were independently assessed for inclusion. They were included if they fulfilled the following criteria:  1.Written and published in English language. 2. Published in peer-reviewed journals. 3.Explain how the level of serum MicroRNA106b may be linked to psoriasis vulgaris.Data Extraction: If the studies did not fulfill the inclusion criteria, they were excluded. Study quality assessment factors included whether ethical approval was gained, eligibility criteria specified, appropriate controls, and adequate information and well-defined evaluation measures. Data from each eligible study were independently abstracted using a data collection form to capture information related to our concerned study outcomes. Conclusions: Serum MicroRNA106b level is lower in patients with psoriasis vulgaris.