Background: In A high rate of death and long-term morbidity are still linked with early-life sepsis caused by bacterial, viral, or fungal infections, despite advancements in newborn care and maternal antibiotic prophylaxis for GBS. Early onset neonatal sepsis (EOS) is a major contributor to sickness and death in the first seventy-two hours of a baby's life. In cases of neonatal septicemia, the C-reactive protein (CRP) test seems to be useful. Progranulin (PGRN) is an autocrine growth factor of 593 amino acids that regulates the crucial TNF/TNFR pathway and is expressed in many mammalian organs. It is a multifunctional immunoregulatory protein. The fields of infectious and inflammatory disorders have conducted much research on it. Methods: Fifty newborns were randomly assigned to the following groups for the research, which took place in a neonatal intensive care unit (NICU): Group I (cases): includes newborns hospitalised to the neonatal intensive care unit due to early onset neonatal sepsis. Apparent healthy newborns made comprised Group II (control). Umbilical cord blood was tested for progranulin levels. Results: Cases and controls did not differ substantially in terms of TLC. Compared to controls (3), cases had a higher median CRP (P=0.001). Patients' progranulin (PGRN) levels were substantially higher than controls' (P=0.001). Conclusion Neonatal sepsis may be indicated by PGRN.