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Klotho G-395A Gene Polymorphism: Impact on Progression of End-Stage Renal Disease and Development of Cardiovascular Complications in Children on Dialysis

Article

Last updated: 05 Jan 2025

Subjects

-

Tags

Medical and Health Science.

Abstract

Background: at In recent years, many indicators have been identified that may predict the likelihood of chronic kidney disease in children who already have certain risk factors. But it's still not easy to accurately measure danger. Goal: This research set out to examine the relationship between cardiovascular problems in juvenile patients on hemodialysis for end-stage renal illness and klotho gene polymorphisms (G-395A). Procedures and Materials: Fifty children participated in the case control study; twenty were on maintenance hemodialysis for end-stage renal disease, ten were on conservative therapy for chronic kidney disease, and ten were healthy controls. All forty kids were genotyped for Klotho G-395A and evaluated for clinical and echographic variants. Findings: Compared to control children, children with chronic kidney disease (both conservative and hemodialysis patients) had much higher frequencies of the GA + AA genotype. The frequencies of the G and A alleles were also significantly different. When looking at the two groups side by side, we can see that the GG and GA+AA frequencies were significantly different between the control and hemodialysis groups, but not between the conservative and hemodialysis groups. On the other hand, the AA genotype frequency was significantly different between the conservative and control groups, as well as between the hemodialysis and control groups. In conclusion, CKD risk factors increased the likelihood of development in children carrying the AA or GA genes, which are examples of wild genes.

DOI

10.21608/bjas.2024.274459.1344

Keywords

Hemodialysis, klotho, Klotho G-395A, Chronic Kidney Disease, End-Stage Renal Disease (ESRD) Thesaurus

Authors

First Name

Ahmed

Last Name

M. Ezzat

MiddleName

-

Affiliation

Pediatrics Department, Faculty of Medicine, Benha University

Email

ahmedmahmoud@gmail.com

City

-

Orcid

-

First Name

Doaa

Last Name

R. Soliman

MiddleName

-

Affiliation

Pediatrics Department, Faculty of Medicine, Benha University

Email

doaarefaey@gmail.com

City

-

Orcid

-

First Name

Inas

Last Name

A. Elsayed

MiddleName

-

Affiliation

Pediatrics Department, Faculty of Medicine, Benha University

Email

inasabdel-elmonem@gmail.com

City

-

Orcid

-

First Name

Wesam

Last Name

Afifi

MiddleName

El-Menshawy

Affiliation

Assistant Professor of Pediatrics and Neonatology Faculty of Medicine – Benha University

Email

wesamel-menshawy@gmail.com

City

-

Orcid

-

First Name

Mona

Last Name

E. Afifi

MiddleName

-

Affiliation

Pediatrics Department, Faculty of Medicine, Benha University

Email

mona990kamal@gmail.com

City

-

Orcid

-

First Name

Ahmed

Last Name

S. Abd El Haleem

MiddleName

-

Affiliation

Pediatrics Department, Faculty of Medicine, Benha University

Email

-

City

-

Orcid

-

Volume

9

Article Issue

2

Related Issue

46894

Issue Date

2024-02-01

Receive Date

2024-02-04

Publish Date

2024-02-01

Page Start

69

Page End

76

Print ISSN

2356-9751

Online ISSN

2356-976X

Link

https://bjas.journals.ekb.eg/article_348568.html

Detail API

https://bjas.journals.ekb.eg/service?article_code=348568

Order

8

Type

Original Research Papers

Type Code

1,647

Publication Type

Journal

Publication Title

Benha Journal of Applied Sciences

Publication Link

https://bjas.journals.ekb.eg/

MainTitle

Klotho G-395A Gene Polymorphism: Impact on Progression of End-Stage Renal Disease and Development of Cardiovascular Complications in Children on Dialysis

Details

Type

Article

Created At

28 Dec 2024