Background: In psoriasis patients, circulating endocan is associated with disease severity and cardiovascular risk. Once again, endocan levels were correlated with inflammatory markers; individuals with psoriasis had greater amounts than controls. Elevated endocan levels may indicate inflammatory and endothelial factors contributing to erectile dysfunction pathophysiology (ED). As a new diagnostic indicator for the degree of erectile dysfunction, endocan could be helpful. The purpose of this review is to examine erectile dysfunction, serum endocan levels, psoriasis epidemiology, and pathophysiology in great detail. The endothelial and inflammatory components of the aetiology of both psoriasis and erectile dysfunction may be represented by increased endocan levels, according to the conclusions. One possible use for endocan is as a diagnostic marker for erectile dysfunction and psoriasis.