Background: Neurotensin (One of the many skin-related physiological functions is that of a vasoactive neuropeptide (NT), which is involved in wound healing, pain regulation, and inflammation. Stress causes the secretion of NT, making it a potential biomarker and connection in mental-cutaneous problems. Discovering NT's function in the skin might lead to new understandings of disease mechanisms and possible treatment avenues. The purpose of this essay is to show how NT is involved in various dermatoses. Its goal is to investigate the physiological role of NT and the processes that lead to its dysregulation. In conclusion, NT is a key molecule with several functions in the field of dermatology. Its altered expression levels and signalling pathways provide light on stress-related skin illnesses, including rosacea, melanoma, psoriasis, vitiligo, alopecia areata, and atopic dermatitis. The discovery of new treatments for various dermatoses may be possible via targeting NT.Neurotensin is a blood pressure regulator,