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363635

Soluble CD163 as a biomarker for renal involvment in systemic lupus erythematosus patients

Article

Last updated: 28 Dec 2024

Subjects

-

Tags

Applied and Basic Science.

Abstract

Introduction:Urine-soluble CD163 (usCD163) is released from alternatively activated macrophages which play an important role in the pathogenesis of lupus nephritis. This study explored the role of usCD163 in patients with systemic lupus erythematosus (SLE). Subject and methods: usCD163 concentrations were measured cross-sectionally in 40 SLE patients and 20 apparently healthy volunteers, age and sex matched. Clinical and laboratory data were collected, a renal biopsy was obtained and SLE disease activity scores were calculated to assess the correlation with usCD163. Results: SLE patients with high usCD163 levels tended to have higher proteinuria, more pyuria and hematuria, higher levels of inflammatory markers, lower complement 3 (C3) levels, higher anti-double-stranded DNA antibody (anti-dsDNA Ab) levels, and higher disease activity scores (p < 0.001). usCD163 levels were significantly higher in patients with active lupus nephritis (LN) than in those with active extrarenal or inactive SLE and correlated with disease activity, and anti-dsDNA Ab levels. Conclusions: Urinary soluble CD163 reflects histologic inflammation in lupus nephritis and is a promising non-invasive biomarker for the assessment of renal disease in SLE patients.

DOI

10.21608/bjas.2024.267125.1315

Keywords

Keywords: CD163, Lupus nephritis, urine biomarker, renal pathology, Activity index

Authors

First Name

Ahmed

Last Name

El-shambaky

MiddleName

-

Affiliation

Professor of Rheumatology, Rehabilitation and Physical Medicine Faculty of Medicine - Benha University

Email

ahmedyousef@gmail.com

City

-

Orcid

-

First Name

Nashwa

Last Name

Hashaad

MiddleName

-

Affiliation

Professor of Rheumatology, Rehabilitation and Physical Medicine Faculty of Medicine - Benha University

Email

nashwaismail@gmail.com

City

-

Orcid

-

First Name

Inas

Last Name

Elsayed

MiddleName

-

Affiliation

Professor of medical biochemistry and molecular biology Faculty of Medicine - Benha University

Email

inasabdelmonem@gmail.com

City

-

Orcid

-

First Name

Abeer

Last Name

Mahmoud

MiddleName

-

Affiliation

(MSc Rheumatology, Rehabilitation and Physical medicine) (Faculty of Medicine, Benha University)

Email

abeerabdelbar85@gmail.com

City

-

Orcid

-

Volume

9

Article Issue

1

Related Issue

46893

Issue Date

2024-01-01

Receive Date

2024-01-01

Publish Date

2024-01-21

Page Start

155

Page End

160

Print ISSN

2356-9751

Online ISSN

2356-976X

Link

https://bjas.journals.ekb.eg/article_363635.html

Detail API

https://bjas.journals.ekb.eg/service?article_code=363635

Order

20

Type

Original Research Papers

Type Code

1,647

Publication Type

Journal

Publication Title

Benha Journal of Applied Sciences

Publication Link

https://bjas.journals.ekb.eg/

MainTitle

Soluble CD163 as a biomarker for renal involvment in systemic lupus erythematosus patients

Details

Type

Article

Created At

28 Dec 2024