Background: Warts, human papillomavirus (HPV) infections often show resistance to standard treatment options, calling for the investigation of potential substitutes. There is encouraging evidence that hydrogen peroxide (H2O2) may alleviate a range of skin disorders. The purpose of this research was to determine whether or not common warts might be safely and effectively treated with topical 40% hydrogen peroxide. Methods The patient is a 36-year-old guy who smokes and has several common warts on his right hand. Applications of H2O2 accounted for 40% of the treatment (twice -weekly for four weeks). Size measurements, picture comparisons, evaluation of side effects, and patient satisfaction were all part of the evaluation process. Results After one month of therapy with 40% hydrogen peroxide, the treated wart showed some improvement. Conclusions: It seemed that a 40% solution of hydrogen peroxide was not the best approach to treating common warts initially.Size measurements, picture comparisons, evaluation of side effects, and patient satisfaction were all part of the evaluation process. Results After one month of therapy with 40% hydrogen peroxide, the treated wart showed some improvement. Conclusions: It seemed that a 40% solution of hydrogen peroxide was not the best approach to treating common warts initially.