Objectives: The analysis of psoriasis patients' blood levels of micro-RNA 22 (MiR-22). Context: While MiR-22 has been implicated in the development of other autoimmune disorders, nothing is known about its function in psoriasis and its therapeutic or diagnostic potential. Data Sources: Studies that investigated the potential function of MiR-22 in psoriasis patients up to the year 2023 were located by searching and examining the Medline databases (Pub Med and Medscape). Study Selection: Each study was carefully reviewed by experts in the field to ensure its inclusion. They were considered for inclusion if they met the following requirements: Language used: English for both writing and publication. Second, they are published in publications that undergo a peer review process. Thirdly, describe the possible relationship between psoriasis patients and serum MiR-22 levels. When extracting data, studies were discarded if they did not meet the inclusion criteria. Ethical permission, clear eligibility criteria, suitable controls, sufficient information, and well-defined evaluation measures were all variables in determining the study's quality. For our concerned research outcomes, data were independently extracted from all qualifying studies utilising a data collecting form. Results: psoriasis patients' levels of MiR-22 expression are much lower than those of the control group.