Background: When a baby breaths in a combination of amniotic fluid and meconium shortly after birth, it may cause meconium aspiration syndrome (MAS). Aim and objectives: Evaluation of Interleukin-6 (IL-6) serum levels in infants whose amniotic fluid has been tainted with meconium. Patient and methods: The subjects of this comparative cross-sectional research were 120 full-term infants whose mothers had MSAF. They were split into One group, called the MAS group, consisted of sixty newborns who had meconium aspiration syndrome, whereas the other, called the control group, consisted of sixty neonates who did not have the condition. Results: For Il-6, there was a positive correlation with trauma, newborn pulse, stuff cells, AST, and ALT, and a negative correlation with haemoglobin and PLT. However, for recurrent infection, PROM, foetal distress, labour complications, white blood cells, CRP, urea, creatinine, bilirubin, sodium, potassium, sulphur dioxide, pH, bicarbonate, and carbon dioxide, there was no statistically significant correlation. Conclusion: There was a strong negative link between Il-6 and Haemoglobin and PLT, but a strong positive correlation with neonatal pulse, stuff cells, AST, and ALT.