Background: ICAM-Intercellular adhesion molecule-1 (ICAM-1) is a gene that encodes a glycoprotein found on the surface of cells that helps them stick together and respond to immunological stimuli. Several research have looked at whether variations in the ICAM-1 gene have a role in acne vulgaris susceptibility (AV). The purpose of this research was to examine ICAM-1 gene polymorphism in acne vulgaris patients. Methods: Fifty people with AV and 30 people who seemed to be healthy served as controls in this prospective case-control study. Genotyping of ICAM-1 gene polymorphism using PCR necessitated a clinical evaluation and blood sample from all individuals. Results: In regards to the ICAM-1 gene's genotypes and alleles: Everyone, including patients and controls, were genotyped. Two percent of AV patients had the AA genotype, thirty percent had the AG genotype, and fifty-six percent had the GG genotype. Forty percent of healthy controls had the AA genotype, 46.7% the AG genotype, and 13.3% the GG genotype. Acne vulgaris was strongly associated with the GG genotype. In conclusion, ICAM-1 gene polymorphism may increase AV patients' vulnerability.