Background: The The nuclear receptor PPAR- has several roles in controlling metabolic and cellular activities. Recent years have brought increased focus on the roles played by inflammation, lipid metabolism, and immune response regulation in the development of dermatological diseases. PPAR- has several functions in skin biology, and expanding our knowledge of these might help in the treatment of a variety of skin problems. This review aims to evaluate the role of PPAR- in skin diseases. We also discuss its significance in skin biology, from keratinocyte regulation to sebaceous gland function. The use of PPAR- agonists in the treatment of inflammatory skin disorders, viral infections, autoimmune diseases, and hair difficulties is something we want to raise awareness of. PPAR- is emerging as a complicated player in dermatology, and our findings demonstrate its profound impact on skin health and disease. This protein regulates inflammation, lipid metabolism, and the immune response, making it a promising therapeutic target. Psoriasis, atopic dermatitis, and scarring alopecia may all benefit from PPAR- agonists in the future as new therapy alternatives.