Background: The physiological process of ovarian aging is accompanied by a decrease in oocyte number & quality. Objectives: To compare the impact of PRP Injection alone & PRP with gonadotropins on ovarian Reserve in poor ovarian Responders (PORs) patients under laparoscope guidance. Patients & methods: This is Prospective controlled research, that had been carried at carried out at the obstetrics & gynecology department at Benha University from March 2023 till September 2023. 60 patients were included from the obstetrics & gynecology department at Benha University Hospital & some private centers. Patients from age 20 to 50 years old with poor ovarian responses participated and were separated into 2 groups, Group A & B. All underwent the laparoscopy for the procedure. Group A consists of thirty studied cases who received PRP Injection, and Group B consists of thirty studied cases who received PRP with gonadotropins. Results: There had been a high statistically significant variation among the 2 studied groups regarding FSH in the Sixth month. Also, there had been statistical variation among different periods in group A as regards AMH. There had been a high statistically significant variation between different periods in group B as regards AMH There had been statistically significant variation among 2 studied groups regarding Estradiol in the Sixth month. Conclusion: Women with premature ovarian insufficiency, particularly those who have tried unsuccessfully to conceive in the past, may benefit from intra-ovarian PRP injections because they are safe, effective, & all-natural.