Background: The Sexual dysfunction and interpersonal violence have been reported as common social and health problems brought on by the COVID-19 pandemic. It is critical for public health and policymaking that we comprehend how the pandemic will affect these concerns. The goal of this descriptive study is to examine the incidence of sexual dysfunction and domestic violence during COVID-19 quarantine measures and to compare these figures to those from before the pandemic. It also examines the causes, symptoms, and diagnostic and therapeutic approaches to sexual dysfunction. It also looks at social isolation and other variables that may have contributed to an increase in domestic violence during the epidemic. Conclusions: An increase in sexual dysfunction, especially erectile dysfunction, has been seen in the wake of the COVID-19 pandemic. This is likely attributable to the virus's effect on endothelial function. Stress, economic instability, and restrictions on migration have all been linked to increases in domestic violence during quarantine times. Both sexes reported reduced levels of sexual pleasure during the COVID-19 epidemic. Anxiety and despair were more common among men.