Background: ED is disease with several potential causes, including high blood pressure and diabetes. Serum endocan, MPV, and NLR are only a few of the biomarkers suggested to measure the severity of this inflammatory response. The goals of this study are to examine the relationship between erectile dysfunction and serum endocan level, mean platelet volume, and neutrophil-to-lymphocyte ratio. Serum endocan Level, Mean Platelet Volume, and Neutrophil to Lymphocyte Ratio in patients with erectile dysfunction were retrieved from the Medline databases (Pub Med and Medscape) until the year 2022. Research Studies were chosen after being objectively evaluated by two reviewers. If they met any of the following criteria, we considered them for inclusion: First, it must be written in English. 2. Appearing in journals with a strict peer review process. Third, explain why serum endocan, MCV, and the neutrophil-to-lymphocyte ratio are important in ED patients. Extraction of Data: Research Studies were not included if they did not meet the inclusion criteria. Ethical permission, eligibility criteria, controls, information, and well-defined evaluation measures were all factors in determining the study's quality. Our concerned research results were captured by independently abstracting data utilising a data collecting form from each qualifying study. We conclude that Endocan, MPV, and NLR are indicators implicated in the pathogenesis of ED in individuals with diabetes and hypertension. Endocan and MPV are markers of erectile dysfunction severity in people with diabetes and hypertension.