Background: Acne vulgaris is a prevalent skin disorder characterized by various inflammatory lesions. The pathogenesis of acne involves complex interplays of multiple factors, including increased sebum production, inflammation, and immune responses. Urocortin 3 (UCN 3), a neuropeptide with diverse physiological functions, has been implicated in skin barrier function and immune modulation. However, its role in acne vulgaris remains poorly understood. Objective: This descriptive review aims to provide an overview of UCN 3, explore its known physiological functions, elucidate the pathogenesis of acne vulgaris, and discuss the multifactorial nature of acne development, considering genetic, environmental, and lifestyle factors. Conclusions: The reviewed literature indicates that Urocortin 3 (UCN 3) holds potential implications in acne pathogenesis, as evidenced by its presence in acne-affected skin and altered serum levels in acne patients. Its known physiological functions in stress regulation, inflammation, and immune responses suggest possible roles in acne development and severity. While specific mechanisms remain unclear, exploring UCN 3's interactions with known acne-related pathways may unveil novel therapeutic targets for acne management.