Background: Cervix cancer is a main cause of illness and death globally among women. It is the second most prevalent cancer and the leading cause of cancer-related death in women. To combat the condition, it is necessary to create a screening test with high specificity and sensitivity. Aim of the Work: to compare Visual Inspection with Acetic Acid, Visual Inspection with Lugol Iodine and colposcope Accuracy in Cervical Neoplasia Screening. Patients and Methods: This study is a Cross-sectional study this study was conducted in Obstetrics and Gynecology department at Benha University hospitals. The study period was carried out from February 2022 to January 2023. Results: In the current study, the mean age was 38.93±7.2 years and the most common age category was 40-50 years in 25 (38.5%) patients. In the present study, most of the studied cases 58 (89.2%) were House wife, only 4(6.2%) cases were nurse and 3 (4.6%) were Teacher. As regard to contraception, the most common Contraception used was IUCD in 34 (52.3%), then 8 (12.3%) cases used Cocs, 4(6.2%) cases used Pops and also tubal ligation, 3 (4.6%) cases used DMPA. Conclusion: The saying “preventable but not prevented" still applies to cervical cancer because there are currently no screening methods that are 100% sensitive and have good specificity. As a result, in the current study, an effort has been made to assess the colposcopy, VILI and VIA both separately and compined.