Background: The incidence of renal stones among children has increased significantly. Generally, congenital anatomical deformities, metabolic disorders, and recurrent urinary tract infections lead to renal stones in the childhood age population. This is why padiatrics are at higher risk of recurrent urolithiasis formation and may undergo multiple surgical interventions Methods: This prospective study included 19 patients with single renal stone (pelvis or lower calyx) 10-20 mm in size, were prospectively collected and randomly divided into three groups, A (F-URS), B (Mini-Perc) and C (ESWL). F-URS was performed using flexible ureteroscope. Mini-Perc was performed using rigid paediatric nephoscope and the stones were fragmented or dusted in groups A and B using holmium:YAG laser. ESWL was performed using a piezoelectric lithotripter device under fluoroscopy guidance. Results: There were no significant differences observed regarding stone site, side, size, and density. Operative time significantly differed between the studied groups, it was significantly higher in group B than in groups A and C, with no significant difference between groups A and C. Fluoroscopy time significantly differed between the studied groups, it was significantly higher in group B than in groups A and C. No significant differences were reported regarding blood loss and auxiliary procedure need. Conclusions: ESWL, mini-PCNL and RIRS are safe and effective in treatment of renal stones measuring 10-20 mm in children aging less than sixteen years old.