Bakeground: Physical measures are from one primary goal of alternative medicines and commonly cited as a probable remedy for primary dysmenorrhea. Aim: of the present work was to assess instructional guideline influence regarding physical measures on primary dysmenorrhea among nursing students. Design: A quasi experimental design pre/post-test one group was employed. Setting: This research was carried out at Benha University Hospital, technical nursing institution. Sample: 218 nursing students were involved as a purposive study sample. Tools: Data gathering was performed using 4 tools: An interviewing questionnaire to collect data related to sample and menstrual characteristics, Verbal multidimensional scoring system, Visual Analogue scale and Likert scale. Results: the present work assumed that a highly substantially critical change was found between symptoms of primary dysmenorrhea at pre and post- intervention and a highly substantially critical change was present among studied sample satisfaction and pain intensity of dysmenorrhea at post intervention phase (Р-value ≤ 0.05). Conclusion: Dysmenorrheal symptoms and pain were alleviated after implementation of an instructional guideline regarding physical measures than before implementation. Also there was a highly statistically critical association among studied sample satisfaction and pain intensity of dysmenorrhea at post intervention phase (Р-value ≤ 0.05).Consequently, the study hypothesis was confirmed. Recommendation: Physical measures as dysmenorrheal treatment are needed to develop and dissemination of illustrated guideline to control and relief of dysmenorrheal syndrome among nursing students and women in other ages.