Background: CPNB known as "perineural infusion of local anesthetic" is the catheter placement next to a peripheral nerve, preceded by local anesthetic administration through catheter, which gives anesthesia/analgesia for many days or even months. CPNBs may be delivered in a hospital setting, but mobile infusion using mobile, lightweight pumps is also a possibility. The most prevalent use of this technique is postoperative pain control. Treating intractable hiccups is considered one of the included other indications; initiating vasodilation to raise blood supply and sympathectomy after catastrophic vascularity, digit transfer/replantation, or limb salvage; relieving Raynaud's disease vasospasm; and treating chronic pain and peripheral embolism, such as complex regional pain syndrome, phantom limb pain, trigeminal neuralgia, and cancer-induced pain. Perineural infusion may give analgesia after trauma while transit to a distant medical facility or while awaiting surgical repair. Catheter installation may be achieved utilizing various different methods, involving nerve stimulation, ultrasound guiding, paresthesia induction, fluoroscopic imaging, and basic tactile sensations ("facial click"). This article provides a review of the existing literature on continuous peripheral nerve blocks supported by evidence.